Missandei was born on the island of Naath in the Summer Sea, off the coast of the continent of Sothoryos. She was enslaved at a young age and taken to Slaver's Bay in Essos, where she was eventually put to work as an interpreter for the slaver-master Kraznys mo Nakloz, one of the Good Masters of Astap. 

Missandei later in life became the loyal trusted avisor and handmaiden to the future Queen Daenerys Targaryen. She met and fell in love with her soul mate Grey Worm. She leaves behind no family but a host of friends and allies.